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Dermatology Online Journal

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Reactive angioendotheliomatosis associated with cyroglobulinemia in a marathon runner


We report a case of a 65-year-old marathon runner who presented with painful plaques, which were worse in cold weather and  progressed to ulceration. A punch biopsy revealed vascular endothelial hyperplasia and an appearance consistent with reactive angioendotheliomatosis (RAE), a rare, but benign disorder of the skin.  Subsequent  investigations  resulted  in  the  diagnosis  of  type  I cryoglobulinemia; the  lesions  resolved  completely  following  treatment  of the underlying disorder with lenalidomide.

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