The Meyerson phenomenon in a teenager
Published Web Locationhttps://doi.org/10.5070/D37bm1s4wm
The Meyerson phenomenon in a teenagerUnit of Dermatology, Oasi Institute (IRCCS), Troina, Italy. email@example.com
Carmelo Schepis MD, Maddalena Siragusa MD
Dermatology Online Journal 14 (2): 28
|Figure 1. Multiple perinevic dermatitis over the trunk|
We evaluated a 12-year-old teenager because of the almost simultaneous occurrence, approximately 1 month earlier, of erythematous papulosquamous changes around small acquired nevi. On clinical examination we found at least seven nevi on the trunk (1.5-2.0 mm in diameter) surrounded by a ring of inflammation with irregular and not well defined margins (Fig. 1). We made a diagnosis of Meyerson phenomenon for which we did not require further exams and invited the parents to return after 6 months for a followup visit.
Meyerson (1971) firstly described two patients with a papulosquamous eruption surrounding some of the nevi on the trunk and limbs . He reported the histology for both cases showing acanthosis, spongiosis, and parakeratosis associated with a lymphocytic perivascular infiltrate in the upper dermis. Meyerson hypothesized that these findings are an atypical form of pityriasis rosea. In subsequent reports, this eruption has been termed Meyerson phenomenon (MP)[2, 3], Meyerson nevus [4, 5], halo dermatitis, and halo eczema [6, 7].
Although Meyerson postulated this eruption to be the localization of pityriasis rosea around melanocytic nevi, that association is not clear. Even though pityriasis is common, MP is rare . It more often involves a single nevus but may affect multiple nevi. Moreover, MP may occur around normal nevi, atypical nevi [2, 9], cutaneous tumors such as seborrheic keratoses , basal cell carcinoma, squamous cell carcinoma, dermatofibroma , keloid, stucco-keratosis, and insect bites .
The histological analysis shows parakeratosis, acanthosis and sometimes epidermal spongiosis. The upper dermis has a perivascular lymphocytic infiltrate, sometimes with eosinophils [2, 4, 9, 10]. Thus, the histological exam has little value for the diagnosis of this condition.
The pathogenesis of MP is still unclear, even if the upregulation of ICAM-1 seems to suggest a role for these cytokines . The lack of the expression of interleukin-2 receptor by T lymphocytes in the infiltrate suggests that the process differs from that of allergic contact dermatitis .
Meyerson phenomenon is rarely encountered in adults and even more rarely in children; some authors hypothesize that a greater awareness of this phenomenon by specialists would result in more numerous reports .
Meyerson phenomenon does not require treatment; it tends to disappear with time. Local application of cortisone [2, 3] can be taken employed in those cases with a particularly intense inflamation and pruritus . For the differential diagnosis, it is important to consider halo nevus , pityriaris rosea , and the roseola of syphilis.
In conclusion, MP is rare event with an unclear pathogenesis and a benign and non recurring course.
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