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Dermatology Online Journal

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Benign familial pemphigus ( Hailey-Hailey disease)

  • Author(s): White, Forrest;
  • Shvartsbeyn, Marianna;
  • Meehan, Shane A;
  • Urbanek, Richard W
  • et al.

A 56-year-old man presented with a 15-year history of scaly red plaques on the trunk and axillae. Skin biopsy was consistent with Hailey-Hailey disease. His condition was refractory to multiple therapies, which included topical and oral antibiotics and topical, intralesional, and oral glucocorticoids. Treatment with subcutaneous botulinum toxin type A at the axillae and on the back led to a nearly complete resolution of plaques in those areas. Botulinum toxin type A should be considered in patients with extensive Hailey-Hailey disease who are fail traditional therapies.

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