Skip to main content
eScholarship
Open Access Publications from the University of California

Dermatology Online Journal

Dermatology Online Journal bannerUC Davis

Treatment of porokeratosis with fluorouracil and salicylic acid under occlusion

  • Author(s): Danby, William, MD
  • et al.
Main Content

Therapeutic pearl: Treatment of porokeratosis with fluorouracil and salicylic acid under occlusion
William Danby MD
Dermatology Online Journal 9 (5): 33

Dartmouth Medical School

A 58-year-old commercial pilot declined surgery for a 1.1 cm biopsy-proven lesion of porokeratosis on his heel, shown here after the biopsy site had healed (fig. 1). After 13 months of treatment with salicylic acid and 5-fluorouracil he was cured (figs. 2, 3 and 4). Salicylic acid (17 %) in collodion was applied under waterproof tape at night. A 1-cm diameter hole was cut in a Duoderm™ patch before it was applied in the morning. Adrucil™ (fluorouracil parenteral for IV Injection) was dropped into the hole, which was then sealed with waterproof tape. The treatment was messy but effective.


Figure 1 Figure 2

Figure 3 Figure 4

© 2003 Dermatology Online Journal