Table 9-Mechanisms of Treatment for Condyloma5,56

Table 9-Mechanisms of Treatment for Condyloma^5,56

Treatment	Mechanisms of action

Imiquimod	Cell-mediated immune response modifier; induces interferon production
Interferon	Antiviral, antiproliferative, and immunomodulatory activity
Podophyllotoxin solution or gel	Cytotoxic, antimitotic; major biologically active component of podophyllin resin
Podophyllin resin	Cytotoxic, antimitotic (causes tissue necrosis)
Trichloroacetic acid Cryotherapy Surgical excision Loop excision Carbon Dioxide Laser Electrosurgery	Protein coagulation of wart tissue Destruction by thermal-induced cytolysis Decrease in virally infected tissue burden Decrease in virally infected tissue burden, Destruction by tissue coagulation and thermal induced cytolysis Destruction by tissue coagulation and thermal induced cytolysis Destruction by tissue coagulation and thermal induced cytolysis

Adapted from Kodner and Nasraty.⁵