Table 2.  Selected case reports in which acanthosis nigricans improved with treatment of the underlying condition.  (*) HAIR-AN = hyperandrogenism, insulin resistance, and acanthosis nigricans, (**) case series, all 10 patients with Cushing syndrome and AN improved

 

Condition

Treatment(s)

Obesity/Hyperinsulinemia

Diet/weight loss[78]

 

Octreotide[79]

HAIR-AN*

Bariatric surgery[80]

 

Hypocaloric diet and weight loss[81]

 

Ketoconazole[82]

Cushing syndrome**

Transsphenoidal surgery[83]

Congenital generalized lipodystrophy

Leptin[84]

Nicotinic acid use

Nicotinic acid discontinued[40]

Amprenavir use

Substitution with efavirenz[45]

Triazinate (folate antagonist) use

Triazinate discontinued[85]

Gastric adenocarcinoma

5-fluorouracil, cisplatin, epirubicin[86]

Melanoma

Excision[65]

Primary biliary cirrhosis

Liver transplantation[39]