Appendix A. Relapses by Clinical Stage

                                                                                                 

Clinical Stage

Type of Relapse

Relapse Rate

Reference

IA

L

0.45%

[Urist 1985; Schmid-Wendtner 2003]

[Balch 2001]?

LN

2%

[Rousseau 2003]

macroscopic = 2%

[Balch 1980 ; Balch 2001]

S

1.59%

[Kang 2005]?

(Calc Balch) [Balch 2001]

M

2.1%

[Balch 1980 ; Balch 2001]

IB

L

1.48%

[Urist 1985; Schmid-Wendtner 2003] [Balch 2001]

LN

9%; S

[Rousseau 2003]

macroscopic = 18.18%

[Balch 1980 ; Balch 2001]

S

3.16%

[Kang 2005] [Balch 2001]

M

6.52%

[Balch 1980 ; Balch 2001]

IIA

L

4.86%

[Urist 1985] [Balch 2001]

LN

24% S

 

[Rousseau 2003]

macroscopic 45.53%

[Balch 1980 ; Balch 2001]

S

7.16%

[Kang 2005] [Balch 2001]

M

12.49%

[Balch 1980 ; Balch 2001]

IIB

L

8.23%

[Urist 1985] [Balch 2001]

LN

3.4% S

[Rousseau 2003]

macroscopic 58.34%

[Balch 1980 ; Balch 2001]

S

9.00%

[Kang 2005] [Balch 2001]

M

30.37%

[Balch 1980 ; Balch 2001]

IIC

L

13.2%

[Urist 1985] [Balch 2001]

LN

53%; S

[Rousseau 2003]

macroscopic 62%

[Balch 1980 ; Balch 2001]

S

8.95%

[Kang 2005] [Balch 2001]

M

72%

[Balch 1980 ; Balch 2001]

IIIA

L

15.7%

[Fincher 2003; Calabro 1989]

LN

14%

[Pidhorecky 2001; Fincher 2003]

S

27%

[Calabro 1989]

M

66.8%

[Calabro 1989]

IIIB

L

15.6%

[Calabro 1989]

LN

20.65%

[Pidhorecky 2001] [Balch 2001]

S

17%

[Calabro 1989]

M

67.4%

[Calabro 1989]

IIIC

L

15.6%

[Calabro 1989]

LN

28% after TLND

[Pidhorecky 2001]

S

12.9%

[Calabro 1989]

M

76.7%

[Calabro 1989]

 

L = local; LN = lymph node; S = satellite/in-transit; M = metastasis; PALP = palpable; TLND = total lymph-node dissection.