Table 1. Response of underlying cancer to treatment with EGFR inhibition in reported cases of trichomegaly. All cases associated
with trichomegaly occurred in females and associated no progression of the tumor (either stable disease or an objective response
of the cancer).
Publication | Patient age and gender | EGFR
inhibitor |
Effect on
Eye lashes |
Type of Cancer | Response of Cancer | Time from starting EGFR inhibitor to development of trichomegaly |
Braideth F et al. 2008 | 57 F | Erlotinib | Trichomegaly | Lung | Major response | N/A |
Lane K et al. 2007 | 70 F | Erlotinib | Trichomegaly | Lung | Durable stable disease and symptomatic improvement | Several months |
Zhang G et al. 2007 | Case 1 :58 F | Gefitinib&
Erlotinib |
Trichomegaly | Lung | Stable disease or better | N/A |
Zhang G et al. 2007 | Case 2:
87 F |
Gefitinib | Trichomegaly | Lung | Stable disease or better | 8 months |
Carser JE et al. 2996 | 61 F | Erlotinib | Trichomegaly | Lung | Stable disease and symptomatic improvement | 3 months |
Bouche O et al. 2005 | 74 F | Cetuximab | Trichomegaly | Rectal | Stable disease | 5 months |
Dueland S et al. 2003 | 26 F | Cetuximab | Trichomegaly | Colon | Tumor response
(47% shrink) |
10 weeks |
Pascual JC et al. 2004 | 51 F | Gefitinib | Trichomegaly | Lung | Significant
response |
7 weeks |
Garibaldi DC et al. 2007 | 49 M | Cetuximab | Maderosis | Colon | Tumor progression | weeks |