| Off-label Indications for Imiquimod |
| Disease name |
Study first author/year [# participants] *=Randomized controlled trial |
Study description (w=week, m=month, d=day, qd=once a day, bid=twice a day, apps=applications) |
Clearance (%) P=Partial C=Complete N=No response |
% with no evidence of recurrence X follow-up period |
Comments |
| Lentigo maligna |
|
|
|
|
|
|
Naylor 2003 [28]* |
|
93C |
80% 1yr |
|
|
Powell 2004 [12] |
qhs-3x/w x 5m |
100C |
100% 18m,100% 9m |
|
|
Ahmed 2000 [1] |
qd-3x/w x 7m |
100C |
100% 9m |
|
|
Fleming 2004 [6] |
qd x 6w |
66P/C |
|
|
|
Kupfer-Bessaguet 2004 [2] |
3x/w x 5m |
100C |
100% 14m,13m |
|
|
Curiel-Lewandrowski 2004 [1] |
qd x 4 w, q3d x 6m |
|
|
|
|
Epstein 2003 [1] |
qd x 5w |
100C |
100% 18m |
|
|
Fisher 2003 [1] |
qhs-3x/w x 9m |
100C |
100% 17m |
|
|
Micantonio 2005 [1] |
qd-5x/w x 12w |
100C |
100% 24m |
|
| Cutaneous melanoma metastases |
|
|
|
|
|
|
Bong 2002 [3] |
qd x 21-28w |
66P |
|
|
|
Hesling 2004 [1] |
qd x 8w |
100C |
|
|
|
Steinmann 2000 [1] |
3x/w x 12w |
100P |
|
|
| |
Ugurel 2002 [1] |
qd x 12w |
100C |
|
|
|
Zeitouni 2005 [1] |
28w |
100C |
|
|
|
Lonsdale-Eccles 2006 [1] |
q2d x 3w, qd x 3m |
100C |
100% 14m |
|
| Intraepithelial melanoma of oral mucosa |
|
|
|
|
|
|
Spieth 2006 [1] |
3x/w x 3m, 2x/w x 3m |
100C |
100% 13m |
|
| Dysplastic nevi |
|
|
|
|
|
| |
Dusza 2006 [10] |
3x/w x16w |
29P |
|
|
| Bowen’s disease: SCC in situ |
|
|
|
|
|
|
Mackenzie-Wood 2001 [16] |
qd x 16w |
100 C |
100% 6m |
|
|
Smith 2002 [5] |
qd x 16w |
100C |
100% 14m |
With sulindac 200mg |
|
Danielsen 2003 [1] |
3x/w x 5w |
|
|
|
|
Micali 2003 [2] |
8-10w |
100C |
100% 6m |
|
|
Gutzmer 2002 [1] |
3x/w x 20m |
100P |
100% 6m |
|
|
Kim 2006 [1] |
3x/w x 16w |
100P |
100% |
|
|
Rodriguez 2005 [1] |
3x/w x 5w |
|
|
|
|
Poluri 2005 [1] |
3x/w x2m |
100C |
100% 7m |
|
|
Brannan 2005 [1] |
bid-q2d x 1m, qd x 2m |
100C |
100% 5m |
|
|
Prinz 2004 [4] |
3x/w x2w, qd x 4w |
75C |
75% 6m |
|
|
Wu 2003 [1] |
q2d x 9w |
100C |
100% 1yr |
|
|
Smith 2001 [5] |
bid x 16w |
100C |
100% 5-14m |
With sulindac 200 mg bid |
|
Peris 2006 [10] |
5x/w x 16w |
25P, 80C, 71C |
100% 31m |
|
| Spindle-cell carcinoma in situ |
|
|
|
|
|
|
Martinez 2006 [1] |
4x/w x 8w |
100C |
100% 1yr |
|
| Vulvar intraepithelial neoplasia (VIN) |
|
|
|
|
|
|
Van Seters 2002 [15] |
3x/w x 34w |
60P, 27C |
|
|
|
Todd 2002 [15] |
3x/w x 16w |
|
|
|
|
Le 2006 [23] |
qw x 2w, 2x/w x 2w, 3x/w x 12w |
24P, 43C |
|
|
|
Haidopoulos 2005 [7] |
3x/w x 8w |
86P |
|
|
|
van Poelgeest 2005 [17] |
2x/w x 16w |
76-100C |
|
|
|
Marchitelli 2004 [8] |
3x/w x 16w |
25P, 75C |
|
|
|
Wendlings 2003 [12] |
3x/w x 7m |
33P, 25C, 41N |
|
|
|
Campagne 2003 [1] |
10apps x 8w |
100C |
100% |
|
|
Diaz-Arrastia 2001 [8] |
3x/w x 6-16w |
25P, 50C |
100% 3-33m |
|
| Vulvitis circumscripta plasmacellularis |
|
|
|
|
|
|
Frega 2006 [2] |
2x/w x 2w, 3x/w x 8w |
100C |
100% 3y |
|
| Anal intraepithelial neoplasia |
|
|
|
|
|
|
Kreuter 2004 [2] |
3x/w x 16w |
100C |
|
|
|
Wieland 2006 [28] |
3x/w x 16w |
14P, 61C |
|
|
| Penile intraepithelial neoplasia |
|
|
|
|
|
|
Dirschka 2006 [1] |
qd x 12w |
|
|
|
| Erythroplasia of Queyrat |
|
|
|
|
|
|
Micali 2006 [1] |
3x/w x 4w, 2x/w x 4w |
100C |
100% 6m |
|
| Bowenoid papulosis |
|
|
|
|
|
|
Richter 2003 [1] |
3x/w x 14w |
100P |
100% 18m |
|
|
Goorney 2004 [1] |
q2d x 2m |
100C |
100% |
|
|
Ruocco 2004 [1] |
3x/w x 8w |
100P |
|
|
|
Godfrey 2003 [1] |
q2d x 3m |
100C |
100% 1yr |
With podophylin 25% |
|
Loo 2003 [1] |
qhs x 12w |
100C |
|
|
|
Petrow 2001 [1] |
q2d x 10d, qd x 10d |
100C |
100% 18m |
|
| Cutaneous extramammary Paget’s disease |
|
|
|
|
|
|
Cohen 2006 [1] |
3x/w x 16w |
|
|
|
| Squamous cell carcinoma |
|
|
|
|
|
|
Pehoushek 2001 [1] |
qhs x 16w |
100C |
100% 3m |
With fluorouracil |
|
Martin-Garcia 2005 [1] |
5x/w x 12w |
100C |
|
|
|
Fernandez2005 [1] |
qd x 12w |
100C |
100% 1yr |
|
|
Schroeder 2006 [1] |
qd x 11d, qd x 13d |
100C |
100% 18m |
|
| Keratoacanthoma |
|
|
|
|
|
|
Dendorfer 2003 [4] |
q2d x 4-12w |
|
|
|
|
Di Lernia 2004 [2] |
3-5x/w x 8w |
100C |
100% 1yr |
|
|
Denkler 2006 [1] |
qd x 3d, q2d x 12d |
100C |
|
|
| Verrucous carcinoma |
|
|
|
|
|
| |
Schalock 2006 [2] |
qd x 10m, qd x 30m |
50C |
|
With interferon alfa |
| Actinic cheilitis |
|
|
|
|
|
|
Smith 2002 [15] |
3x/w x 4-6w |
100C |
100% 4w |
|
| Precancerous and cancerous lesions of chronic arsenicism |
|
|
|
|
|
|
Boonchai 2006 [1] |
qd x 4w, 3-5x/w x 4w |
100C |
100% 2yr |
|
| Intraepidermal Carcinoma |
|
|
|
|
|
|
Hengge 2001 [2] |
3x/w x 17w, 3x/w x 9w |
100C |
100% 15m; 100% 17m |
|
| Infiltrative trichilemmal carcinoma |
|
|
|
|
|
| |
Jo 2005 [1] |
|
100C |
|
|
| Nodular BCC |
|
|
|
|
|
|
Wu 2006 [17] |
qd x 6-10w |
|
|
|
|
Spencer 2006 [10]* |
qd x 1m |
10P, 90C |
|
|
|
Blasi 2005 [2] |
3x/w x 8-12w |
100C |
100% 1yr |
|
| Cutaneous T-cell Lymphoma |
|
|
|
|
|
|
Didona 2004 [2] |
3x/w x 6w |
100C |
100% 8m |
|
|
Suchin 2002 [1] |
qhs x 4m |
100P |
100% 10m |
|
|
Coors 2006 [8] |
|
25P, 25C |
|
|
| Lymphomatous skin deposits in chronic lymphocytic leukemia |
|
|
|
|
|
| |
Spaner 2005 [1] |
qd x 6w |
100C |
100% 10m |
|
| Angiolymphoid hyperplasia |
|
|
|
|
|
|
Redondo 2004 [1] |
5x/w x 16w |
100C |
100% 4m |
|
| Lymphomatoid papulosis |
|
|
|
|
|
| |
Hughes 2006 [1] |
3x/w x 4w |
100C |
100% 2w |
|
| Mycosis fungoides |
|
|
|
|
|
|
Deeths 2005 [6] |
3x/w x 12w |
75C, 25P |
66% 2yr |
|
|
Soler-Machin 2006 [1] |
3x/w x 5m |
100C |
100% 5m |
|
|
Ariffin 2006 [1] |
2x/w x 2w, qd x 4w |
100C |
100% 6m |
|
| Adult cutaneous Langerhans cell histiocytosis |
|
|
|
|
|
| |
Taverna 2006 [1] |
5x/w x 2m |
100C |
100% 6m |
|
| Kaposi's sarcoma |
|
|
|
|
|
|
Rosen 2006 [1] |
qd x 4m |
100C |
100% 6m |
|
| Breast cancer |
|
|
|
|
|
| |
Hengge 2005 [2] |
5x/w x 6m |
100C |
|
|
| Herpes simplex virus 2 |
|
|
|
|
|
| |
Gilbert 2001 [1] |
3x/w x 1w |
100P |
100% 1m |
|
| |
Danielsen 2002 [1] |
|
100C |
|
|
| Herpes labialis |
|
|
|
|
|
|
Bernstein 2005 [30]* |
3x/w x 1w |
|
|
|
| Recurrent, acyclovir-resistant genital herpes. |
|
|
|
|
|
|
Martinez 2006 [2] |
2-3x/w x 2w, qid x 1m, qd x 3m |
100C |
100% 10-12m |
|
| Molluscum contagiosum |
|
|
|
|
|
|
Bayerl 2003 [15] |
3x/w x 16w |
54P, 15C |
|
|
|
Ross 2004 [16] |
qhs x 5w |
75P |
|
|
|
Buckley 1999 [1] |
3x/w x 3m |
100C |
100% 5m |
|
|
Yazdani 2003 [3] |
bid x 6m |
50C |
|
|
|
Barba 2001 [12] |
qhs x 4w |
33C |
|
|
|
Strauss 2001 [1] |
3x/w x 13w |
100C |
100% 5m |
|
|
Hengge 2000 [50] |
5x/w x 16w |
|
|
|
|
Syed 1998 [100] * |
tid-5x/w x 4w |
|
|
|
|
Gardener [1] |
3x/w x 6m |
100C |
100% 6m |
|
|
Arican 2006 [9] |
3x/w x 16w |
92P, 8C |
100% 3m |
|
| Common, Plantar, Flat, Subungal, and Periungal Warts |
|
|
|
|
|
| |
Goihman-Yahr 2006 [4] |
q2d x 1m |
100C |
100% 1-3yr |
|
| Juvenile verrucae planae |
|
|
|
|
|
|
Muhlstadt 2007 [1] |
2x/w x 4w |
100C |
|
|
| Epidermodysplasia verruciformis |
|
|
|
|
|
|
Carre 2003 [1] |
3x/w x 4w |
100C |
|
|
| Focal epithelial hyperplasia (Heck’s) |
|
|
|
|
|
|
Maschke 2002 [1] |
3x/w x 3m |
100 C |
100% 5m |
|
| Papillomatosis |
|
|
|
|
|
|
Rinne 2000 [1] |
3x/w x 3m |
100C |
100% 4m |
|
| Human Orf (ecthyma contagiosum) |
|
|
|
|
|
| |
Erbagci 2005 [4] |
bid x 5-10d |
100C/P |
|
|
| Hyalohyphomycosis |
|
|
|
|
|
| |
Erbagci 2005 [1] |
qd x 30apps |
|
|
With itraconazole 200mg bid |
| Tinea pedis |
|
|
|
|
|
| |
Stashower 2006 [1] |
qd x 4w, bid x 10w |
100C |
|
|
| Leishmaniasis |
|
|
|
|
|
|
Arevalo 2001 [12] |
q2d x 20d |
50P, 50C |
90% 6m |
|
|
Miranda-Verastegui 2005 [40]* |
q2d x 20d |
|
|
|
| Porokeratosis of Mibelli |
|
|
|
|
|
|
Agarwal 2002 [1] |
5x/w x 5w |
100C |
100% 1yr |
|
|
Harrison 2003 [1] |
3x/w x 6w |
100C |
100% 24m |
|
|
Jain 2006 [1] |
5x/w x 2w, 2x/w x 6w |
100C |
100% 1yr |
|
| Stucco keratosis |
|
|
|
|
|
|
Stockfleth 2000 [1] |
3x/w x 5w |
100c |
|
|
| Seborrheic keratosis |
|
|
|
|
|
|
Herron 2004 [2] |
qd x 6m, bid x 6m |
100C |
|
|
| Trichoepitheliomas |
|
|
|
|
|
| |
Urquhart 2005 [1] |
3x/w-bid x 3yr |
80C |
|
With tretinoin |
| Keloids |
|
|
|
|
|
|
Uysal 2006 [9] |
qd x 4w |
100C |
72% |
|
| Post-surgical scar cosmesis |
|
|
|
|
|
| |
Berman 2005 [20]* |
qhs x 4w |
|
|
|
| Hypertrophic scars |
|
|
|
|
|
| |
Prado 2005 [15] |
q3d x 8w |
|
100% 24w |
|
| Exuberant granulation tissue |
|
|
|
|
|
| |
Lain 2005 [1] |
4x/w x 7m |
100C |
100% 2w |
|
| Post-face peel healing |
|
|
|
|
|
|
Prado 2005 [12] |
qd x 12w |
100C |
|
|
| Chronic radiation dermatitis |
|
|
|
|
|
|
Sachse 2006 [1] |
qd x 2w |
100C |
100% 2yr |
|
| Silicone granuloma |
|
|
|
|
|
|
Baumann 2003 [1] |
bid x 2w |
100C |
100% 4w |
|
| Granuloma annulare |
|
|
|
|
|
|
Kuwahara 2002 [1] |
6w |
100C |
|
|
|
Kuwahara 2003 [1] |
6w |
100C |
|
|
| Pyogenic granuloma |
|
|
|
|
|
|
Ezzel 2006 [1] |
qd x 2w, q2d x 4w |
100C |
100% 4m |
|
| Infantile hemangioma |
|
|
|
|
|
|
Martinez 2002 [2] |
3x/w x 3m |
100C |
100% 7m |
|
|
Welsh 2004 [10] |
5x/w x 16w |
75-95C |
70% 4m |
|
| Alopecia Totalis/Universalis. |
|
|
|
|
|
|
D'Ovidio 2002 [15] |
3x/w x 15w |
|
|
|
| Discoid lupus erythematosus |
|
|
|
|
|
|
Gul 2006 [1] |
3x/w x 7w |
100C |
|
|
| Morphea |
|
|
|
|
|
| |
Dytoc 2005 [12] |
3x/w x 3m |
100P |
100% 6m |
|
| Xeroderma pigmentosum |
|
|
|
|
|
|
Giannotti 2003 [1] |
3x/w x 4-6w |
100C |
100% 6m |
With acitretin 20mg qd |
|
Nagore 2003 [1] |
5x/w x 6w |
100P |
100% 8m |
|
|
Roseeuw 2003 [2] |
3x/w x 6w, 3x/w x 10w |
|
|
|
|
Weisberg 2002 [2] |
bid, 3x/w |
100P |
|
|
|
Nijsten 2005 [1] |
3x/w x 14m |
100C |
|
|
| Vitiligo |
|
|
|
|
|
|
Bong 2004 [12] |
3x/w x 6w |
100N |
|
|
| Elastosis perforans serpiginosa |
|
|
|
|
|
|
Kelly 2006 [1] |
qhs x 6w, 3x/w x 4m |
100C |
100% 3m |
|
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