A 68 year old man with an 18 month history of untreated biopsy-proven
granuloma annulare on the trunk and extremities and normal blood glucose was
started on pentoxiphylline (Trental) 400 mg. This was taken twice or three
times a day for 3 months with partial resolution of the granuloma annulare.
ASA 325 mg daily was added, Trental was continued, and the granuloma annulare
improved to a great extent over the next 6 weeks. Granuloma annulare remained
well controlled with Trental and ASA at followup after an additional 2
months.
Conclusion: ASA plus Trental may be better than Trental alone for granuloma annulare.
Kevin C. Smith MD FRCPC