CALCIPOTRIENE
===================

 
From: Mark R Ling <mling@emory.edu>
  

I'm curious as to the evidence that calcipotriene and UV-B work via 
common mechanisms. I had presumed that Vit. D derivatives worked through 
the nuclear Vitamin D receptor and thus through calcineurin and 
ultimately via inhibition of NFAT (excuse the molecular biology mistakes, 
I'm no immunogeneticist!), whereas the mechanism of UV-B was less well 
characterized but via a distinct mechanism. Is anyone out there familiar 
enough with current concepts to explain to non-basic scientists like me 
the current thoughts about the underlying mechanisms, and whether they 
are comparable? 
P.S. the low temp on Saturday even here in sunny Atlanta is predicted to 
be 12 degrees. Don't know about your patients, but mine would gladly pay 
for a little "sunlight in a tube" considering the alternative.

Mark Ling, M.D., Ph.D.