We want to create a system that provides the same advance for full text and information within that text that MEDLINE provided for titles and abstracts. In order to provide optimal access to your work and to specific parts of your work, we need you to pay close attention to headings, subheadings, and key words. There are several major headings in a manuscript: Abstract, Introduction, Methods, Results, Conclusions, and References. In addition, you may have minor headings that fall under each heading, and key words may occur in various locations throughout your manuscript. We are trying to key on the important information in your manuscript by using a hierarchical system of headers, subheaders, and keywords. For example, the treatment of Sweet(s) syndrome might by viewed, in part, this way:

Here is the abstract of the article. Generally given in one paragraph, but you may use more as necessary. The abstract will end at the subsequent header. Do not give citations within your abstract.

This key word signals the end of contents of the previous key word (abstract) and introduces your topic. Citations within your article should be noted by square brackets [1]. Please list the reference before the punctuation mark. References may also fall within a sentence [2] when limited to information in the first part but not the second part of the sentence. When you need to list more than one reference, please list all the numbers [3, 4, 5, 6]. Separate each reference with a comma. This will allow hypertext information to be tied to each number. For example, the article on Sweet's syndrome allows the reader to see the citation simply by putting the mouse over the reference number.

There is nothing special about the methods section, per se. Therefore we will discuss the use of images within the manuscript.

Know that you may be liberal with your illustration. The journal has the convention of using in-line 192*128 pixel illustrations linked to full-size versions of the image. When you wish to display one illustration, it will float to the right of the text. Two illustrations will, by default, be placed side by side on the same line. For example, see the article on trichoepithelioma in the May Journal.

You may indicate the placement of your figures by using an all-caps designation before the appropriate paragraph:

This would result in the placement of the figure and its associated legend to the right of this paragraph. If you think a different placement is more optimal, you need to convey that information to the Editor when the manuscript is submitted.

This will result in two figures,side-by-side, and their accompanying legends appearing before the start of this paragraph.

Throughout the manuscript, you may wish to use tables or diagrams for illustration. You need to indicate the proper placement of these elements. In general, tables should be less than 420 pixels wide to be included inline. Othwise we will simply provide a hypertext link to the table. In any case, please create the tables, one per file (you may use Microsoft Word to create the tables--using the save as Web Page option).

The above indicates the placement of a table on a line by itself. This will result in the table and associated legend appearing between paragraphs.

In addition to headers, you may use subheaders and key words in your manucript. Here is an example of indicating those elements from the article on Sweets disease. The headings and key words have been changed to red to make them more visible for the purposes of demonstration.

     B:Topical corticosteroids

Topical and intralesional corticosteroids have been used frequently as adjunctive treatment along with systemic modalities. They are used occasionally as solo therapy and can be effective in mild cases [3, 4].

Indomethacin appears promising as an alternative to corticosteroids. It was first reported as useful in 1977[20]. Most recently,17 of 18 patients responded with clearing to indomethacin [6]. No recurrences were noted in a mean follow-up of 20 months. The dosage used was as follows: 150 mg per day for 1 week, 100 mg per day for 2 weeks. Indomethacin was then stopped. Fever and arthralgia were attenuated within 48 hours. The eruption cleared within 7-14 days. Naproxen was used successfully in one patient with CML [21].

Some authors state that potassium iodide (KI) may be as effective as corticosteroids and that relapses may be less frequent [2]. However, the reports of KI use tend to be older and smaller numbers of patients were treated than in reports utilizing corticosteroids. Nevertheless, several studies have shown effective clearing with the use of KI [19, 22, 23, 24]. In these studies, 900 mg per day was initiated. Symptoms improved within 48 hours and cutaneous lesions cleared within 1 week in most cases. In some cases the drug was withdrawn after only 2 weeks and no recurrence was seen [22]. Two patients developed a severe vasculitis that was attributed to KI [19, 25].

To reiterate:

• major headers are on a line by themselves and are preceded by a Roman numeral with no space.
• secondary headers are on a line by themselves and are preceded by a Tab followed by a capital letter.
• keywords are indicated in the Keyword section of the header.