Patient's Course On follow up examination one week later his eruption had almost completely cleared. Gianotti-Crosti Syndrome: a reactive exanthem associations Hepatitis B1 Epstein-Barr virus2 coxsackie virus3 cytomegalovirus3 parainfluenza virus4 clinical characteristics mostly ages 2-6 predominantly acral papules often lymphadenopathy resolves in 3-5 weeks laboratory evaluation lymphocytosis (54-73%) increased liver enzymes4 histopathology lymphocytic perivascular infiltrate spongiosis papillary dermal edema Because of the association with known viruses, it is essential to perform appropriate serologic tests. Hepatitis B, in particular may be present without any other signs or symptoms of infection.

References 1)Gianotti F. Rilievi di una particolare casistica tossinfettiva caratterizzata de eruzione eritemato- infiltrativa desquamativa a focolai lenticolari, a sede elettiva acroesposta. G Ital Dermatol 1955;96:678-97. 2)Lowe L, Hebert AA, Duvic M. Gianotti-Crosti syndrome associated with Epstein-Barr virus infection. J Am Acad Dermatol 1989;20:336-8. 3)Taieb A, Plantin P, du Pasquier P, et al Gianotti-Crosti syndrome: a study of 26 cases. Br J Dermatol 1986;115:49-59. 4)Spear KL, Winkelmann RK. Gianotti-Crosti Syndrome. Arch Dermatol1984:1120:891-896.