Table 2. Factors associated with a poor prognosis

1) Chronic immunosuppression [8, 43]

2) Deep invasion (> 4 mm) [8, 45]

3) High grade or desmoplastic lesions [8, 45]

4) Incomplete excision and recurrence of the primary tumor [6, 8, 9, 54, 55]

5) Large lesions (> 2 cm) [6, 8, 45]

6) Lesions located within the lymphatic drainage of the parotid gland or those on the lower lip [56, 57, 58, 59, 60]

7) Occurrence in non sun-exposed areas [4, 8]

8) Perineural invasion [45, 61]

9) Precursor lesion of Actinic Keratosis [14, 16, 17]