Table 2. Selected case reports in which acanthosis nigricans improved with treatment of the underlying condition. (*) HAIR-AN = hyperandrogenism, insulin resistance, and acanthosis nigricans, (**) case series, all 10 patients with Cushing syndrome and AN improved

Condition	Treatment(s)
Obesity/Hyperinsulinemia	Diet/weight loss[78]
	Octreotide[79]
HAIR-AN^*	Bariatric surgery[80]
	Hypocaloric diet and weight loss[81]
	Ketoconazole[82]
Cushing syndrome^**	Transsphenoidal surgery[83]
Congenital generalized lipodystrophy	Leptin[84]
Nicotinic acid use	Nicotinic acid discontinued[40]
Amprenavir use	Substitution with efavirenz[45]
Triazinate (folate antagonist) use	Triazinate discontinued[85]
Gastric adenocarcinoma	5-fluorouracil, cisplatin, epirubicin[86]
Melanoma	Excision[65]
Primary biliary cirrhosis	Liver transplantation[39]