Table 1. Clinical and immunohistochemical findings in six patients with sebaceous
neoplasms.
|
Patient Gender/age |
Personal tumor history |
MLH1 |
MSH2 |
MSH6 |
Family
tumor history |
Diagnosis |
|
Patient 1 F/56 |
Sebaceous adenoma Keratoacanthoma BCC Colon cancer |
- - - - |
+ - + + |
+ - + + |
Colon (6) |
Muir-Torre syndrome |
|
Patient 2 F/74 |
Sebaceous adenoma SCC Colon cancer |
+ + + |
- - - |
- + - |
Stomach (1) Ovary (2) |
Muir-Torre syndrome |
|
Patient 3 F/44 |
Sebaceous carcinoma |
- |
+ |
+ |
Colon (1) |
Probable Muir-Torre syndrome |
|
Patient 4 F/38 |
Sebaceous adenoma ID nevus |
+ + |
+ + |
- + |
None |
Probable Muir-Torre
syndrome |
|
Patient 5 F/ 74 |
Sebaceous
adenoma BCC |
+ + |
+ + |
+ + |
Stomach (1), endometrium (1) , pancreas (1),
testicle (1), breast (2) |
Sporadic sebaceous adenoma vs Muir-Torre syndrome |
|
Patient 6 F/64 |
Sebaceous adenoma |
+ |
+ |
+ |
None |
Sporadic sebaceous adenoma |
BCC: basal cell carcinoma
SCC: squamous cell carcinoma
ID: intradermal