Table 6.

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                                    Psoriasis Vulgaris skin lesions                            HIV Peripheral blood

ÒType 1Ó cytokines:

IL-2                                          ­                                                                      ø

IFN-γ*                                       ­                                                                      ­  or   ↔

TNF-α                                       ­                                                                      ø

 

ÒType 2Ó cytokines:

IL-4                                          ø or absent                                                         ­  or  ↔

IL-5                                          ?                                                                       ­  or  ↔

IL-6                                          ø                                                                      ­

IL-10                                         ø or absent                                                         ­

 

 

 

Plasma/B Cells                           absent or few                                                      ­

IgG                                           absent or low                                                      ­

______________________________________________________________________________________

 

 

Table 6. Relative cytokine profiles in peripheral blood T cells of HIV patients and from T cells in

psoriatic lesions. Note the opposite cytokine expression in psoriatic skin compared to HIV peripheral

blood for all cytokines except IFN-γ, which is increased in both cases. (↑, increased; ↓, decreased; ↔, stable;

?, no published data available; *,CD8+ lymphocytes are primarily responsible for this increased production

of IFN-γ)