PSORIASIS
 
Left-Right Arrow Callout: – Curved Down Arrow: HIV

ÒTYPE 2Ó CYTOKINES
 

ÒTYPE 1Ó CYTOKINES
 

IL4

IL5

IL6

IL10
 

IL2

TNF-α

IFN-γ
 
Figure 2.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Figure 2. Classic cytokine profiles and their associations with HIV and psoriasis.

Specifically, IL2, IFN- γ, and TNF-α are considered Type 1 cytokines, while

IL4, IL5, IL6, and IL10 are considered Type 2 cytokines. Type 1 and Type 2 cytokines

negatively counter-regulate each otherÕs production. The psoriatic phenotype is promoted

by type 1 cytokines, whereas HIV infection is classically thought to promote a Type 1 to

Type 2 cytokine shift.