Table 3- Trials relating to podophyllotoxin

Reference	Patients	Design	Clearance	Recurrence
Lacey et al 2003^13	358	Randomized controlled	Compares podophyllotoxin solution, podophyllotoxin cream, and podophyllin. Podophyllotoxin showed greater efficacy and cost effectiveness than clinic based treatment with podophyllin.	No data
Tyring S et al, 1998 ^15	326	Double-blind, randomized trial	After 8 weeks, 64% treated with 0.5% podofilox gel were cleared versus 12% in the vehicle-treated group. The 0.5% podofilox gel was generally well tolerated, with predominantly mild or moderate local reactions	No data
Claesson et al 1996 ^16		Randomized prospective study	Compared podophyllotoxin cream 0.15% and 0.3% versus 0.5% solution, showing no statistically significant differences between the 3 treatments with regard to both efficacy and safety.	No data
Bonnez W, et al, 1994 ^17	103	Randomized Controlled Trial	Showing efficacy and tolerance of 0.5% podofilox in the treatment of anogenital warts.	Podophyllotoxin is superior when patient-administered over the vehicle alone as prophylaxis against recurrence of lesions.