Table I: Main differences between DLE in children and adults (1-7)

	DLE in children	DLE in adults
Epidemiology	No female predominance/ photosensitivity +	Female predominance/ photosensitivity +++
Clinically	Localized DLE	Localized DLE
Cutaneous histology	Epidermal damages +/- BMZ anomalies Dermal lymphocytic infiltration. T helper cells +++	Epidermal damages ++ BMZ anomalies Dermal lymphocytic infiltration. T helper and suppressor cells +++
DIF in lesional skin	Granular IgG, IgM or complement deposits along BMZ (80%)	Granular IgG, IgM or complement deposits along BMZ (50 to 90%)
TTT/Outcome	Photoprotection, TC+ +/- AM/ Frequent progression to SLE (about 30%)	Photoprotection, TC+ +/- AM/ Possible progression to SLE (6%)

BMZ: Basement membrane zone, DIF: Direct immunofluorescence, TTT: Treatment, AM: Antimalarials, TC: Topical corticosteroid